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Traditional proteomics-based methods, such as N-terminomics 37,38,39 and proteomic identification of protease cleavage sites 40 , are well suited for global analyses of protease activity but can be low throughput and may lack the sensitivity to detect low-frequency, yet biologically perturbative, off-target cleavage events

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Isoprenaline control rats exhibited hemorrhagic gastric lesions (5.5 ± 1.0, means ± SD, mm, sum of the longest lesions diameters), while BPC 157-treated rats had spared gastric mucosa ( p ˂ 0.05, vs

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